Who Is Affected By PCS?
PCS is most commonly identified in women between the ages of 20 and 45 who have had two or more pregnancies, though it is not limited to this group. The following categories of women are recognised in the clinical literature as being at higher risk:
-
Women who have had two or more pregnancies
Each pregnancy increases the cumulative strain on venous valves in the pelvis through increased blood volume and mechanical pressure from the growing uterus. Pelvic vein capacity is estimated to increase by up to 60% during pregnancy.
-
Women who have had a single pregnancy
Though less common, PCS can occur after one pregnancy.
-
Women with hormonal risk factors
Conditions associated with elevated oestrogen levels, such as polycystic ovary syndrome (PCOS), or the use of oestrogen-containing therapies, may increase susceptibility, as oestrogen is known to weaken vein walls and promote venous dilatation.
-
Women with a family history of varicose veins or venous insufficiency
A genetic predisposition to weak vein walls may increase susceptibility.
-
Post-menopausal women
PCS is predominantly a condition of reproductive-age women and symptoms commonly improve after menopause. However, emerging case evidence suggests PCS can occasionally persist or present in post-menopausal women, particularly where pelvic veins have been significantly dilated previously. This remains an area of limited systematic research.
It is important to note that the absence of a pregnancy history does not exclude PCS. Women who have not had children can also develop pelvic venous disorder, particularly when an anatomical compression variant such as nutcracker syndrome or May-Thurner syndrome is present.